02. Re.belle woman

Well, that is up for debate and what you mean by age.

These products are about DNA-repair and cleaning out some old ones.

Analogies can be helpful in understanding complex biological processes. Let's compare sirtuin activity with a disc reader of a CD:

1. The CD and Its Tracks: Imagine that the CD represents the DNA in our cells, and the tracks on the CD represent specific genes or regions of the DNA. Just as a CD has various tracks with different songs, DNA has different genes that encode various proteins.

2. The Disc Reader: The disc reader, which reads the tracks on the CD, can be likened to enzymes that "read" or interpret DNA. In our analogy, the sirtuins can be thought of as a specialized type of disc reader.

3. Reading Accuracy and Modifications: Over time, CDs can accumulate dust, scratches, or other imperfections that can interfere with the disc reader's ability to play the songs. Similarly, DNA can accumulate modifications or damage over time. Acetylation (the addition of an acetyl group) of proteins associated with DNA, like histones, can affect how genes are read or expressed. This is where sirtuins come in: they "clean" these acetylations (like a disc cleaner might remove dust or smudges), ensuring that genes are read correctly.

4. NAD+ as the Power Source: Just as a disc reader requires electricity to function, sirtuins require NAD+ to conduct their deacetylation activity. Without NAD+, sirtuins can't "clean" or deacetylate the DNA, much like a disc reader won't work if unplugged.

5. The Impact of Age: As mentioned before, CDs can wear out or get scratched with repeated use over time, affecting playback quality. Similarly, as cells age, DNA can accumulate damage, and NAD+ levels can decline, reducing sirtuin activity. This might lead to genes being "read" or expressed inappropriately, contributing to age-related cellular dysfunction. This is what to believed to be aging.

In summary, in this analogy, sirtuins act like a specialized disc reader that ensures the accurate "playback" of genes by cleaning or deacetylating the DNA (akin to removing smudges from a CD). NAD+ acts as the power source for this activity, and the efficiency of this "playback" can decrease with age, much like how an old, scratched CD might not play as well as it once did

1. Supplement Dosage: Over-the-counter NMN supplements often suggest dosages ranging from 125 mg to 500 mg per day, with some individuals choosing to take more based on personal research or physician recommendations. For example Professor David Sinclair eats 1000 mg/ per day.
2. Clinical Trials: The dosages used in clinical trials can differ based on the objectives of the study. Some human trials have investigated doses up to 500 mg or more per day.
3. Safety Considerations: Preliminary studies suggest that NMN is safe at the doses commonly found in supplements. However, comprehensive long-term safety data in humans is limited.
4. Formulation: NMN can be found in various forms, including capsules, powders, and sublingual (under the tongue) formulations. Some believe that sublingual formulations might have better bioavailability, although conclusive evidence is lacking.
5. Other Factors: The specific reason for supplementation, individual health status, and potential interactions with other medications or supplements can all influence the appropriate dose.

Because NMN is relatively new in the context of popular supplements, and its long-term effects and optimal dosage are still subjects of ongoing research, it's crucial to consult with a healthcare professional if you're considering taking NMN. They can offer guidance based on the latest research and your individual health needs.

Disclaimer:These products are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare professional before starting any new supplement.

How They Might Work Together;

1. Synergy in Metabolic Health: Both berberine and resveratrol have been shown to improve markers of metabolic health, possibly helping with insulin sensitivity and overall energy metabolism. When combined with NMN or NR, which replenishes NAD+ levels (further supporting cellular energy metabolism), there might be a synergistic effect on metabolic health.
2. Cellular Health and Longevity: NMN boosts NAD+ levels, supporting sirtuin activity. Resveratrol directly activates sirtuins. Together, they might have a combined effect on promoting cellular health and potentially counteracting some age-related changes.
3. Energy Stress and AMPK Activation: Berberine's activation of AMPK signals a state of low energy in the cell, which can lead to various protective and metabolic responses. The combination of AMPK activation (by berberine) and sirtuin activation (by NMN and resveratrol) might lead to a coordinated response that promotes cellular health and stress resistance and a decline in so called "zombie cells".

However, it's important to note that while each of these compounds has been studied individually, there's limited research on their combined effects in humans. The potential synergies are largely speculative based on understanding their individual mechanisms.

As always, if you're considering taking any combination of supplements, it's essential to consult with a healthcare professional to ensure they are appropriate and safe for your specific health context.